Positive Month 24 PIVOT-HD interim: votoplam slowed HD progression 52%
PTC reported results from its Phase 2 study of votoplam (PTC518) for Huntington's disease on Apr 28, 2026. The study met its main goal.
Plain-English summary generated from this entry’s own fields (drug, condition, stage, date). Glossary
- Company
- PTC Therapeutics, Inc. PTCT
- Drug
- votoplam (PTC518)
- For
- Huntington's disease
- Stage
- Phase 2 · the stage that tests whether the drug actually works
- When
- Apr 28, 2026
- Source note
- PTC reported positive topline results from the 24-month interim analysis of the PIVOT-HD long-term extension, showing dose-dependent benefit on cUHDRS in Stage 2 Huntington's disease patients versus a matched natural history cohort, with 52% slowing at the 10 mg dose. Novartis has initiated the global Phase 3 INVEST-HD study.
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- Checked by a person when it was added
- Source: ir.ptcbio.com ↗ — where this entry was taken from
- SEC filings (8-K) ↗ — press releases are attached to 8-K filings
- ClinicalTrials.gov ↗ — trials of this drug
- PTCT headlines on this site
FDA engagement on votoplam PIVOT-HD 24-month results in Huntington's disease, expected in the second half of 2026 (no exact date yet). A company milestone for PTC (votoplam (PTC518) for Huntington's disease): a step in the program rather than a decision or a data readout.
More details
- Entry
- FDA engagement on votoplam PIVOT-HD 24-month results in Huntington's disease · Company milestone
- Drug
- votoplam (PTC518)
- For
- Huntington's disease
- Stage
- Phase 3 · the last stage before a drug can be approved
- When
- H2 2026 · the company gave a window, not a day
- Source note
- Company plans to engage with FDA in 2H 2026 to discuss PIVOT-HD 24-month results; outcome frames a potential accelerated path for the Novartis-partnered program.
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- Checked by a person when it was added
- Verify it
- Source: prnewswire.com ↗ — where this entry was taken from
- SEC filings (8-K) ↗ — press releases are attached to 8-K filings
- ClinicalTrials.gov ↗ — trials of this drug
- PTCT headlines on this site
Plain-English summary generated from this entry’s own fields (drug, condition, stage, date). Glossary · Open this catalyst’s page
PTC303 (MSH3 splicing) clinical entry, expected during 2027 (no exact date yet). A company milestone for PTC (PTC303 for somatic expansion disorders (Huntington's disease, myotonic dystrophy)): a step in the program rather than a decision or a data readout.
More details
- Entry
- PTC303 (MSH3 splicing) clinical entry · Company milestone
- Drug
- PTC303
- For
- somatic expansion disorders (Huntington's disease, myotonic dystrophy)
- Stage
- Phase 1 · an early safety study in a small group of people
- When
- 2027 · the company gave a window, not a day
- Source note
- Company plans to enter the clinic in 2027 (year-level guidance only).
- Checked
- Checked by a person when it was added
- Verify it
- Source: prnewswire.com ↗ — where this entry was taken from
- SEC filings (8-K) ↗ — press releases are attached to 8-K filings
- ClinicalTrials.gov ↗ — trials of this drug
- PTCT headlines on this site
Plain-English summary generated from this entry’s own fields (drug, condition, stage, date). Glossary · Open this catalyst’s page