Trial resultsMay 18, 2026162 days ago
Phase 3 TroFuse-005 met OS and PFS endpoints for sac-TMT in endometrial cancer
Merck & reported results from its Phase 3 study of sacituzumab tirumotecan (sac-TMT, MK-2870) for Advanced or recurrent endometrial cancer on May 18, 2026. The study met its main goal.
Plain-English summary generated from this entry’s own fields (drug, condition, stage, date). Glossary
DetailsClinical trial results · also called: readout / topline data
- Company
- Merck & Co., Inc. MRK
- Drug
- sacituzumab tirumotecan (sac-TMT, MK-2870)
- For
- Advanced or recurrent endometrial cancer
- Stage
- Phase 3 · the last stage before a drug can be approved
- When
- May 18, 2026
- Source note
- Sacituzumab tirumotecan significantly improved both overall and progression-free survival versus physician's choice chemotherapy at a pre-specified interim analysis - the first ADC to show this in advanced or recurrent endometrial cancer.
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- Checked by a person when it was added
Check the sourcesdon’t take our word for it
- Source: merck.com ↗ — where this entry was taken from
- SEC filings (8-K) ↗ — press releases are attached to 8-K filings
- ClinicalTrials.gov ↗ — trials of this drug
- MRK headlines on this site
Merck & Co., Inc.
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Merck & expects to report results from its Phase 3 study of sacituzumab tirumotecan (MK-2870) for Advanced/recurrent endometrial cancer (TroFuse-005) in the second half of 2026 (no exact date yet). Phase 3 is the last stage before a drug can be approved, so this result usually decides the program’s future.
More details
- Entry
- Sac-TMT TroFuse-005 endometrial cancer detailed Ph3 data presentation · Clinical trial results (readout / topline data)
- Drug
- sacituzumab tirumotecan (MK-2870)
- For
- Advanced/recurrent endometrial cancer (TroFuse-005)
- Stage
- Phase 3 · the last stage before a drug can be approved
- When
- H2 2026 · the company gave a window, not a day
- Source note
- Merck Aug 4, 2026 Q2 earnings slides list this under milestones 'expected over next six months' (Aug 2026-Jan 2027); no congress named, so H2 2026 is an approximation of that window. Topline (OS and PFS met) was announced in Q2 2026.
- Checked
- Checked by a person when it was added
- Verify it
- Source: merck.com ↗ — where this entry was taken from
- SEC filings (8-K) ↗ — press releases are attached to 8-K filings
- ClinicalTrials.gov ↗ — trials of this drug
- MRK headlines on this site
Plain-English summary generated from this entry’s own fields (drug, condition, stage, date). Glossary · Open this catalyst’s page